Project information

Effective Scarring Treatments

Scarring has profound effects on individuals ranging from cosmetic disfigurement to clinical depression contributing to post-traumatic stress disorder. Our DS Model is an award-winning, validated model of wound healing. The Model will be used to better understand the optimal treatments of scarring.

January 2014 - December 2016

Charity information: Restore - Burn and Wound Research

Restore - Burn and Wound Research logo
  • Need

    Need

    There is poor evidence for virtually all treatments to prevent and treat cutaneous scars. Better understanding of the optimal treatments for scarring will limit the negative effects to the individual and society as a whole. The NHS spends millions of pounds a year on scarring treatments

    Solution

    The Dermal Scratch is an extremely powerful model of wound healing in that it is easy to quantify the amount of scarring resulting from the injury and this scarring can be used as a sensitive index of how well a treatment has worked.The treatment interventions to be tested would in the first instance be those that are purported to reduce scar production, are widely used, but for which there is a poor evidence base.

  • Aims

    Aim 1

    Assessing treatments for scarring

    Activities

    » Establish a multi-centre testing facility

    Outcome measures would include scar dimensions (HFU and photography) and blood flow (LDI). These parameters would be assessed at four follow up visits over 18 months


    Aim 2

    Better understanding of optimal treatments will limit the negative effects to people and society

    Activities

    » Establish a multi-centre testing facility

    This work has not been attempted in a highly standardised manner previously and has the benefit to conclusively improve the morbidity of scarring.


    Aim 3

    Engender major cost savings in the identification of treatments which are not efficacious.

    Activities

    » Establish a multi-centre testing facility

    The treatment interventions to be tested would be those that are purported to reduce scar production, are widely used, but for which there is a poor evidence base.


    Aim 4

    Identify key biochemical markers which are implicated in scarring.

    Activities

    » Establish a multi-centre testing facility

    The aim is to immunostain for these markers in the hope of finding out which cells they associate with and for the most likely targets


  • Impact

    Impact

    Establishing the optimal scar treatments

    Risk

    We fail to raise sufficient funding for the other costs associated with the project - principally Fellows' salaries.

    Reporting

    We will report regularly through our Newsletter, Annual Report and website. We also have occasional briefings from our scientists.

  • Budget

    Budget - Project Cost: £87,320

    Loading graph....
      Amount Heading Description
      £13,660 Episcan Scanning System Purchase & installation at Frenchay Hospital, Bristol
      £13,660 Episcan Scanning System as above for Stoke Mandeville Hospital
      £17,000 Primos measuring Sensor Purchase & installation at Frenchay Hospital, Bristol
      £17,000 Primos Measuring Sensor as above for Stoke Mandeville Hospital
      £10,000 Spectrophotometer Purchase & installation at Frenchay Hospital, Bristol
      £10,000 Spectrophotometer as above for Stoke Mandeville Hospital
      £6,000 Photography system camera systems x 2
  • Background

    Location

    The multi-centre project will have initially two locations - Frenchay Hospital, Bristol and Stoke Mandeville Hospital, Aylesbury. Both hospitals have established plastic surgery units with burns as specialism

    Beneficiaries

    In 2004, nearly 11 million people worldwide were burned severely enough to require medical attention. UK has 250,000 burn injuries, 13,000 hospital admissions, 300 deaths. The average cost in the UK of treatment for a major burn is £63,000

  • Why Us?

    Why Us?

    We have been researching burns and scarring since 1991. We collaborate with Universities and NHS Trusts & partner with research institutions & charities.Our research into burn wounds & scarring is unique. The DS Model was developed by our researchers. We have a lean infrastructure and an excellent track record with a unique research ethos

    Read more about the Charity running this project.

    People

    Jon Pleat

    Director. Jon has designed the project. He developed the DS Model and is the best person to supervise the project. He a consultant burns surgeon