Project information

Trials of the EN2 protein test with urine samples

Surrey University Postgraduate Medical School has developed a ground-breaking new test, the EN2 test, to detect prostate cancer using urine samples. After successful initial studies, they need to carry out a larger trial on around 300 patients so that the test can become available in GP surgeries

January 2013 - December 2013

Charity information

The Prostate Project

The Prostate Project logo
  • Need


    The current PSA (prostate specific antigen) test used for detecting prostate cancer is an important test, saving many thousands of lives every year. However, its use is limited because it often cannot detect the difference between non-cancerous and cancerous cells in the prostate, failing to detect more than half of all cancers, and often leading to "false positive" results. Many men therefore undergo uneccessary surgery and radiation, risking impotence and incontinence in the process.


    A more specific test for prostate cancer is therefore needed urgently. The EN2 urine test can provide this without the need for a blood test. The latest data confirms that the amount of EN2 in urine accurately indicates the amount of cancer present. The EN2 test will guide the urologist as to which patients have very small insignificant prostate cancer and which have larger cancers that need treatment. The proposed trials of 300 patients are needed before this test can be made widely available

  • Aims

    Aim 1

    To carry out trials with urine samples from about 300 patients.


    » Samples will need to be collected, stored, tested and analysed in relation to each patient's medical history. This requires specialist staff support.

    Success will be the necessary further proof that the EN2 urine test works.

  • Impact


    GPs will be able to undertake urine tests on more possible prostate cancer patients to catch the disease early with much more certainty (than using the current PSA blood test) that prostate cancer is or is not present and if it is, to provide the necessary treatment at a much earlier stage thus saving lives and costs, ie, of expensive procedures that are often undertaken uneccessarily today. The comparative statistics will be proof of the success of the new EN2 urine test.


    Lack of sufficient funding. The Prostate Project has already part funded the Post Graduate Medical School Urology team of the University of Surrey with £5 million over the past 14 years with donations.

    The Prostate Project is therefore continuing to raise funds to support the team, undertaking the further EN2 urine test trials in a number of ways, eg, the recent successful walk from John O'Groats to Lands End by a Prostate Project trustee. Funds as well as awareness were both increased.


    Mainly via The Prostate Project website (
    but also in The Surrey Advertiser which is supporting the Prostate Project in its aims by regular publicity and articles about donations and progress.

  • Budget

    Budget - Project Cost: £27,000

    Loading graph....
      Amount Heading Description
      £15,000 EN2 Testing Consumables
      £5,000 EN2 Testing Nurse practitioner time
      £5,000 EN2 Testing Sample co-ordinator time
      £2,000 EN2 Testing Sample procurement and transport
  • Background


    The Post Graduate Medical School of the University of Surrey is situated adjacent to the Royal Surrey County Hospital.


    This project will enable the EN2 urine test to replace the less accurate, and often misleading, PSA blood test in all GP surgeries throughoyt the UK and elsewher in the world.

  • Why Us?

    Why Us?

    With its track record of raising funds to help establish and maintain the team at the PGMS over th epast 14 years, The Prostate Project has regular and intimate knowledge of the team's requirements and personal experience with Professor Hardev Pandha, his doctors, scientists and research staff.

    Read more about the Charity running this project.


    Colin Stokes

    Founder Chairman of The Prostate Project

    Professor Hardev Pandha

    Professor of Urology at the University of Surrey

    Mr Jan Derwig

    Finance Trustee of the Prostate Project. Responsible for managing The Prostate Project funds that support the Post Graduate Medical School team.

    Mr Terry Hinton

    Liaison between The Prostate Project and the University of Surrey.