Project information

Lowe Syndrome Children Antibody

Project to Produce, Characterize, and Make Available to Interested Researchers an Antibody to ‘OCRL’, the Enzyme Protein which is defective in Lowe Syndrome

November 2011 - November 2012

Charity information

The Lowe Syndrome Trust

The Lowe Syndrome Trust logo
  • Need


    To fund a project to produce a Lowe antibody which is urgently required by all the Lowe research teams looking to find a cure for Lowe Syndrome, an incurable children's disease.


    What would the Lowe Trust do with one or more ‘good’ antibodies
    These would be made freely available to bona-fide researchers throughout the world to study the disease and advance the search for a cure for Lowe Syndrome. Distribution of the antibody would be controlled by the Lowe Syndrome Trust’s independent ‘Scientific Advisory Board’ (SAB).

  • Aims

    Aim 1

    • Find out where the Lowe Protein, OCRL is located in the cells of the body


    » Making the Antibody

    Success will be determined by the Lowe research scientists.

    Aim 2

    Characterising the Antibody


    » • Find out how the forms of OCRL present in different patients may cause the disease

    Success will be...determined by the Lowe research scientists.

    Aim 3

    • Measure how much OCRL protein there is in cells from patients


    » Making the Antibody

    Success will be..determined by the Lowe research scientists..

    Aim 4

    • Allow researchers to study the effects of possible treatments at the level of the cell


    » Characterising the antibody

    Success will be...determined by the Lowe research scientists.

  • Impact


    the first Lowe antibody will be available for all Lowe research teams and will be demonstrated in future Lowe projects funded by the LST.


    There are no risks.


    The Trust will update the donators on a regular basis either by letter or email.

  • Budget

    Budget - Project Cost: £65,000

    Loading graph....
      Amount Heading Description
      £15,000 Antibody To produce monoclonal antibody
      £50,000 Lab costs Research assistant and associated reagents
  • Background


    Manchester University under Dr Martin Lowe


    Lowe patients, Lowe carers, Lowe medical professionals, Lowe families

  • Why Us?

    Why Us?

    The Lowe Syndrome Trust is the main charity worldwide funding vital research in the hope of a cure of this devastating children's disease.

    Read more about the Charity running this project.


    Dr Martin Lowe And His Team At Manchester University

    Martin Lowe is a research scientist funded by the Lowe Syndrome Trust

Penny Lancaster with Oscar who has Lowe

Penny Lancaster with Oscar who has Lowe

‘The Lowe Syndrome Trust has made an enormous contribution since it was founded in 2000

Professor Robert Unwin, UCL London