Project information

AMD: addressing sight loss

Age-related macular degeneration (AMD) is a common cause of sight loss in the elderly. This project will build on existing research to provide new insights into the relationship between the genes that are linked to AMD and their impact on the cells of the retina.

October 2011 - September 2014

Charity information: Fight for Sight

Fight for Sight logo
  • Need

    Need

    AMD is the leading cause of blindness in people over 60 in the western world and the impact can be devastating. It damages central vision, making it difficult or even impossible to recognise faces and carry out everyday tasks such as reading and driving. This can lead to a loss of independence and have profound consequences for quality of life.

    Solution

    A group of related genes have been identified as leading to increased susceptibility to AMD, but we need to understand how or why these variants cause disease. The results from this project will provide new insights into the relationship between genes that are linked to AMD and their impact on the cells of the retina.

  • Aims

    Aim 1

    To determine how AMD-associated proteins alter the characteristics of cells in the retina.

    Activities

    » This project will use a set of functional read-outs for selected cells, in order to determine how the AMD-linked proteins change their properties

    The results will provide new insight into the relationship between the genes that are linked to AMD and their impact on the cells of the retina.


  • Impact

    Impact

    The results of this project will not only advance our knowledge of the causes of AMD, they will also be useful in designing models of AMD that are better suited to the development of new therapeutics.

    Risk

    Although unlikely, there is a risk that the PhD student recruited to carry out this research doesn't see it through. We have mitigated this risk by ensuring that the supervisors for the project are experienced and highly regarded in their fields; the facilities available are excellent; and that the research programme is challenging but achievable.

    Reporting

    Funders of this project will receive regular updates on Fight for Sight's progress in preventing and treating blindness. We will send an annual progress report relating to this project, detailing milestones and performance against these.

  • Budget

    Budget - Project Cost: £100,000

    Loading graph....
      Amount Heading Description
      £65,016 Student costs Stipend and PhD fees
      £34,984 Equipment costs Consumables

    Current Funding / Pledges

    Source Amount
    Trusts £56,370 Guaranteed
  • Background

    Location

    The project will be carried out in the UCL Institute of Ophthalmology. The Institute has been at the forefront of vision research in the UK for more than two decades. The depth and breadth of experience, skills and knowledge of vision research at the Institute of Ophthalmology are internationally recognised.

    Beneficiaries

    Age-related macular degeneration is the leading cause of blindness in people over 60 in the western world.

  • Why Us?

    Why Us?

    Fight for Sight is the UK's leading charity dedicated to funding world-class research into the prevention and treatment of blindness and eye disease. As a member of the AMRC, all of the grant applications we receive are subjected to a robust peer review process by global experts in the field to ensure that we only fund the best eye research in UK universities and hospitals.

    Read more about the Charity running this project.

    People

    Professor Stephen Moss, Norman Ashton Chair Of Biomedical Research, UCL Institute Of Ophthalmology

    Prof Moss will be the primary supervisor for the PhD student undertaking this project.

    Professor John Greenwood, Hugh Davson Chair Of Biomedical Research, UCL Institute Of Ophthalmology

    Prof Greenwood will be second supervisor on the project.