Project information

Stem Cells and the Origin of BPH

This project will determine the sensitivity of prostate mesenchymal stem cells to hormones, aiming to determine their role in BPH. Developing our understanding of the role of prostate stem cells in BPH may ultimately lead to targeted treatments with greater efficacy.

3 years initially

Charity information: Prostate Cancer Research Centre

Prostate Cancer Research Centre logo
  • Need

    Need

    This project will determine the sensitivity of prostate mesenchymal stem cells to hormones, aiming to determine their role in BPH. Developing our understanding of the role of prostate stem cells in BPH may ultimately lead to targeted treatments with greater efficacy.

    Solution

    The aim will be to identify cell surface markers on prostate mesenchymal stem cells that can be used for stem cell isolation and ultimately as targets for therapy.

  • Aims

    Aim 1

    Identify prostate mesenchymal stem cell markers using MACs and FACS.

    Activities

    » Flow cytometry will be used to measure the expression profile of putative stem cell markers, including CD73, 90 and 105,

    Success will be...Developing our understanding of the role of prostate stem cells in BPH may ultimately lead to targeted treatments with greater efficacy.


    Aim 2

    Study the expression and distribution of the selected prostate mesenchymal stem cell markers.

    Activities

    » Flow cytometry will be used to measure the expression profile of putative stem cell markers, including CD73, 90 and 105

    Success will be...Developing our understanding of the role of prostate stem cells in BPH may ultimately lead to targeted treatments with greater efficacy.


  • Impact

    Impact

    Nobody really knows what causes BPH, but one theory is altered control of stem cell growth. We are very interested in the normal stem cells because we think they are probably the root of prostate cancer. In fact the normal stem cells are as important to us as the cancer stem cells as they have similar characteristics and so an alternative to targeting the cancer stem cells is to kill all prostate stem cells.

    Risk

    Failure to achieve funding for this project would put the two years work already carried out at risk. We are activley searching for funding from a number of sources.

    Reporting

    Quarterly updates will be given where requested

  • Budget

    Budget - Project Cost: £195,000

    Loading graph....
      Amount Heading Description
      £45,000 Consumables Laboratory equipment needed for this project
      £150,000 Salary Three years salary and oncosts
  • Background

    Location

    UCL London

    Beneficiaries

    Men mainly over the age of 50

  • Why Us?

    Why Us?

    Professor Masters who is overseeing this project has over 20 years experience in this area

    Read more about the Charity running this project.

    People

    Dr Maria Notara

    Project leader

Dr Maria Notara

Dr Maria Notara